Anti-neutrophil cytoplasmic antibodies (ANCA) are usually pathogenic in ANCA-associated vasculitis (AAV) by stimulating polymorphonuclear leucocytes (PMNs) to degranulate and produce reactive oxygen species (ROS). a PR3CANCA mouse model has been described [8]. However, ANCA levels alone cannot predict relapses conclusively [9], and there is an unmet need for better methods to assess the degree of… Continue reading Anti-neutrophil cytoplasmic antibodies (ANCA) are usually pathogenic in ANCA-associated vasculitis (AAV)