Background Accurate staging of rectal tumors is vital for making the right treatment choice. LOH in conjunction with SMAD4 mutations is certainly a well researched sensation in CRC, and SMAD4 gene mutations are linked to advanced tumor stage [39,40]. Immunohistochemistry had not been simple for SMAD2 but was simple for SMAD4 officially, Rabbit polyclonal to… Continue reading Background Accurate staging of rectal tumors is vital for making the