Pregnancy increases the urinary excretion of chemicals in women and rodents. mid to late gestation but returned to control levels by postnatal day 15. CX-5461 In contrast, Mrp3 mRNA and protein increased 225% and 31%, respectively, at gestational day 14. Coordinated down-regulation of brush border transporters Mate1, Mrp2, and Mrp4 and up-regulation of the basolateral… Continue reading Pregnancy increases the urinary excretion of chemicals in women and rodents.