The Fc region of the antibody mediates effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), and plays a key role in the in vivo half-life of an antibody. A330S and P331S). An IgG2m4 antibody has an overall reduction in complement and Fc receptor binding in in vitro binding analyses while maintaining… Continue reading Supplementary MaterialsFigure S1: Correlated prices of evolution are not a general Supplementary MaterialsFigure S1: Correlated prices of evolution are not a general